The base 16 notational system for representing real numbers, called hexadecimal, is particularly important and used extensively in computer science, since four bits (each consisting of a 'one' or 'zero') can be succinctly expressed with just a single hexadecimal digit. The 16 distinct digits used to represent numbers in hexadecimal notation are: 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, A, B, C, D, E, and F.

The human eye sees continuous motion at between 16 and 20 frames per second.

There are 16 orders of mammals.

Romanian constructs the names of the numbers 11 to 19 by a regular pattern which could be translated as 'one-over-ten', 'two-over-ten', etc. All the other Romance languages use a pattern like 'one-ten', 'two-ten', etc. for 11 to 15; and the pattern 'ten-and-seven', 'ten-and-eight', 'ten-and-nine' for 17 to 19. For 16, however, they split into two groups: some use 'six-ten', while others use 'ten-and-six':